A Preliminary Study Indicating Improvement in the Median Survival Time of Glioblastoma Multiforme Patients by the Application of Deuterium Depletion in Combination with Conventional Therapy

Glioblastoma multiforme (GBM) and malignant gliomas are the most common primary brain tumors. Temozolomide (TMZ) chemotherapy plus radiation therapy (RT), admi-mistered after debulking surgery, increased median survival time (MST) from 12.1 months with RT alone merely to 14.6 months, respectively. In this study, actions of deuterium-depleted water (DDW) on GBM patients who also received conventional therapies was investigated. Without changing treatment, daily fluid intake wholly replaced DDW in 1.5–2 L per day volume reduce D concentration their bodies. The endpoint MST. 55 involved treatment consumed DDW, showed a longer MST (30 months) compared historical control (12.1–14.6 months). There massive difference between two genders calculated values; it 25 male subgroup (n = 33) 42 female 22), 27 without TMZ (38 patients) TMZ-treated group (17 patients), For selected 31 patients, correct way addition treatments, as 30 months. Within group, 20 subjects had relapsed before MST, but those 10 were remission when started, 47 began parallel radiotherapy, again started at 8 weeks or later completion radiotherapy. Altogether, these times substantially prolonged prospective clinical data GBM. Consequently, if supplemented depletion, better can be achieved advanced stage than known targeted combination therapies. Application is recommended all stages disease surgery repeated courses advised has been achieved.